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Importin and exportin inhibitors are being considered as therapeutic targets against cancer and have shown preclinical anticancer activity.Moreover, synergistic activity has been observed with various chemotherapeutic and targeted agents.The Biomedical Research Council (BMRC) has the honor of selecting a faculty member for the Distinguished Faculty Lectureship Award in Biomedical Research each year. PMID# 21417406 Grover Madhusudan, Farrugia Gianrico, Lurken Matthew S, Bernard Cheryl E, Faussone-Pellegrini Maria Simonetta, Smyrk Thomas C, Parkman Henry P, Abell Thomas L, Snape William J, Hasler William L, nalp-Arida Aynur, Nguyen Linda, Koch Kenneth L, Calles Jorg Cellular changes in diabetic and idiopathic gastroparesis. Comparative immunology, microbiology and infectious diseases.
Wolf has been a prolific writer (over 200 articles) and mentor to many.
The Biomedical Research Core Facilities (BRCF), part of the UMMS Office of Research, has launched a new website at PMID# 21618260 Bitar K, Greenwood-Van Meerveld B, Saad R, Wiley J W.
During nucleocytoplasmic transport of tumor suppressor proteins and cell cycle regulators during the processing of these proteins, aberrant cellular growth signaling and inactivation of apoptosis can occur, both critical to growth and development of tumors.
Karyopherin-β proteins bind to these cargo proteins and Ran GTP for active transport across the nuclear membrane through the nuclear pore complex.
However, clinical development of the exportin-1 inhibitor leptomycin B was stopped due to adverse events, including vomiting, anorexia, and dehydration.